AMERICAN FORK, Utah, June 6, 2024 /PRNewswire/ -- IBC Advanced Technologies Inc. (IBC) announces commercial availability of specific Molecular Recognition Technologytm (MRTtm) flowsheets for highly selective, single-step separation of actinium-225 (Ac-225) and recycling of radium-226 (Ra-226).
Recent critical global shortages of the therapeutic isotope Ac-225 have caused uncertainty around the availability and sustainability of the isotope's supply chain, and shortages have begun to slow the pace of clinical development, posing an increased risk to continuity of supply in ongoing clinical trials in major cancer indications.
In parallel, increased regulatory scrutiny of the impurity profile of Ac-225, in particular the presence of impurities such as the long-lived radionuclide Ac-227, demands a step-change in the quality, purity and durability of Ac-225 production.
IBC's innovative flowsheets have been designed specifically to equip producers of Ac-225 to streamline and improve their production processes and enhance the recycling recovery rates of valuable target material, especially Ra-226, thereby alleviating critical shortages for a key therapeutic radionuclide.
Flowsheets for the individual separation of Ac-225 and Ra-226 are based on highly selective MRTtm resins and processes, commercially launched by IBC in 2023.
Manufactured exclusively by IBC in the United States, MRTtm resins consist of predesigned, highly metal-selective ligands covalently attached to solid supports, such as silica gel or polymer substrates. MRTtm resins can be reused repeatedly and individually bind Ac-225 and Ra-226 with exceptionally high selectivity in packed column mode. The bound target Ac-225 or Ra-226 is removed via elution with very high rates of purity and recovery, up to 99.99% pure and 99.9+% yield, using chemically simple solutions. Excellent radiolytic stability and reusability of MRTtm resins ensure a sustainable process with minimal waste generation.
Dr. Robert G. G. Holmes, former Chief Scientist at Canadian Nuclear Labs, commented, "IBC offer proven flowsheets for highly selective separation of Ac-225 and Ra-226. The use of MRTtm resins to obtain exceptionally high yields and purities promise to alleviate the current critical supply shortage by making more Ac-225 available."
Steven R. Izatt, President and CEO of IBC, commented, "IBC's proprietary MRTtm resins have been shown to achieve exceptionally high recovery yields and purities, as well as radiolytic stability for multiple cycle reusability. MRTtm flow sheets substantially reduce production time, dramatically increase output and generate minimal waste, thereby resulting in a sustainable process for long-term supply of Ac-225. "
Background of IBC
IBC is an award-winning manufacturer and supplier of highly selective separations products, engineered systems and processes using Molecular Recognition Technologytm (MRTtm). Based on green chemistry and green engineering principles, IBC's MRTtm products and associated processes are used worldwide in medical, mining, metals, manufacturing, environmental, analytical and laboratory applications.
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